Karius
Genomic Insights for Infectious Diseases
Pathogens can be hard to uncover–find them fast with the Karius® Test.
Karius sees a world where infectious disease is no longer a major threat to human health.
When you are empowered with genomic insights to detect infectious diseases sooner, you can get your patients back to health faster – that's Clarity at Speed™.
Global impact of infectious diseases
Over 14 million people/year die from infectious diseases.1
In up to 62% of cases, the pathogens causing life-threatening infections are not diagnosed by conventional methods.2,3
We use genomics and AI to advance infectious disease diagnostics.
Microbial cell-free DNA
Karius provides unique genomic insights by detecting microbial cell-free DNA (mcfDNA) circulating in the bloodstream from pathogens causing an acute infection. Proprietary technology efficiently extracts mcfDNA directly from blood and depletes the strong human background signal and environmental contaminants.
Karius AI technology
Advanced machine learning algorithms allow analysis of complex genomic data in real-time. Proprietary reference genome databases are constantly refined as more data becomes available.
Brian's story
"The Karius Test saved my life by identifying the deadly strain of bacteria (Fusobacterium) that caused my life-threatening pneumonia."
Brian J
Read his full story here
Published studies demonstrate the clinical impact of the Karius Test.
10+ publications
40+ abstracts
10+ clinical trials
Testimonials
“The Karius Test has been a valuable tool in several cases to me to decrease overall testing as well as provide conclusive diagnoses in area of uncertainty. Thank you for continuing to develop diagnostics that improve patient care so significantly.”
Dr. Prerana Roth, Greenville, SC
Infectious Diseases doctor
“The Karius Test is amazing. It’s going to completely change the way we diagnose and manage infectious diseases going forward.”
Dr. Asha Shah, Stamford, CT
Infectious Diseases doctor
"The infectious disease doctors came in and ordered the Karius Test to identify what the infection was, and they found an infection that is normally not diagnosed until after death."
References:
1. Fauci AS. et al, Emerging Infect Dis. 2005 Apr;11(4):519-25
2. Jain et al, NEJM. 2015 Dec 10;373(24):2382.
3. Gupta S. et al, Chest. 2016; 150:1251-1259
Accurately and Quickly Detecting Legionella with the Karius® Test
Legionella is a species of Gram-negative bacteria which can cause pneumonia (Legionnaires’ disease) or a...
Speaker - Lauge Farnaes, MD PhD | Diagnosis and management of pediatric complicated pneumonia using the Karius Test
In this webinar, lead author, Dr. Lauge Farnaes, Assistant Medical Director at Rady Children’s Institute...
New Study Review: Diagnosis and Management of Pediatric Complicated Pneumonia using the Karius Test
In this webinar, Dr. David Hong, VP Medical Affairs and Clinical Development at Karius, discusses a...
Karius Medical Case Report: Finding Lepto
We report the following clinical scenario:
A 42-year-old female presented to hospital with fever, rash,...
Karius Medical Case Report: Detection of Blastomyces dermatitidis
We report the following clinical scenario:
An elderly male from the St. Lawrence River Valley...
Study Validates Karius Test to Identify Life-Threatening Infections
Karius Test Identifies Pathogens More Accurately Than Standard Lab Tests
...
Karius Medical Case Report: The only administered test to detect a case of Strongyloides stercoralis
We report the following clinical scenario:
A 58-year-old male with a history of treatment-refractory multiple...
How to Safely Use a Neti Pot
Sinus irrigation devices help you breathe easier but at rare times can introduce dangerous...
I Wouldn't Be Here Without You: Tom's Story
Dear Karius,
I'm a Vietnam veteran and an elected city official, with three children I'm...
The New World of Infectious Disease Diagnosis: Out in the Field with David Hong of Karius
Karius VP of Medical Affairs and Clinical Development Dr. David Hong recently appeared on a...
Newly Published Case Series Demonstrates the Karius Test’s Effectiveness for Monitoring Infections in Stem-Cell Transplant Patients at Risk of Infections
Karius and Clinical Investigators from UCSF Showed that the Karius Test can Quickly and...
Karius Medical Case Reports: Trypanosoma cruzi
Chagas Disease is an illness that affects 8 million people worldwide and is caused...
Karius Secures $25 Million Additional Funding
Oxford Finance LLC, a specialty finance firm that provides senior debt to life sciences...
Karius and Dasa enter into a partnership to introduce the Karius Test into Brazil
We are excited to announce that Karius is forming a partnership with Dasa, the largest...
Fever of Known Origins: Detecting Infections in Pediatrics with Plasma-based Next Generation Sequencing
This webinar focuses on applications of the Karius Test in pediatrics. Cases presented highlight diagnostic...
Karius’ NGS test for infections shows high sensitivity in pilot study
The study, conducted with St. Jude Children's Research Hospital, showed a 78 percent predictive...
Karius and St. Jude Children’s Research Hospital Show that the Karius Test Might Predict Development of Bloodstream Infections in High-Risk Pediatric Cancer Patients
PREDSEQ Study Demonstrates the Promise of the Karius Test for Predicting Bloodstream Infections Prior...
Karius Announces Winners of the 2018 Clinical Investigator Awards
Two honorees receive a $50,000 grant to fund novel research using the Karius Test to...
Come Join Us for 7 IDWeek 2018 Abstracts
We're excited to announce that Karius collaborators will be presenting seven abstracts at the upcoming...
Analytical Validation of the Karius Microbial Cell-Free DNA Sequencing Test for Infectious Disease
In this webinar, Karius Co-Founder and Chief Scientific Officer Tim Blauwkamp presents results from the...
Detecting invasive fungal infections with a liquid biopsy for infectious diseases
This webinar presents the results of a clinical study that showed how the Karius Test...
How Karius Saved My Life: Brian’s Story
Dear Karius,
I am writing in heartfelt appreciation for the Karius Test, which...
New Clinical Study Data Published on Karius Test in Patients with Invasive Fungal Infections
We are pleased to announce the positive results of a clinical study using blood samples...
Karius Medical Case Reports: Blood Culture-Negative Endocarditis
Blood culture-negative endocarditis is an infection of the heart valves where blood cultures to...
Karius ASM Industry Showcase Webinar: Clinical Application of a Plasma Next-Generation Sequencing Test for Pathogen Detection
This talk was recorded at the ASM Microbe 2018 meeting on Saturday, June 9,...
Deadline for Karius Clinical Investigator Awards Extended to July 13
This is the month to get your application in for the Karius Clinical...
Karius Webinar: Introduction and Clinical Experience with the Karius Test
This is the first of a new webinar series about the clinical use of the...
Karius Announces Launch of Quantitative, Broad-Based Infectious Disease Diagnostic Test Using Microbial Cell-Free DNA
Test Detects and Quantifies DNA from Bacteria, Viruses and Fungi in a Single Blood...
Sequencing Comes to Infectious Diseases
We’re thrilled to be featured on the Mendelspod.com podcast today, featuring Karius CEO Dr. Mickey...
Karius Medical Case Reports: The Race to Diagnose Sepsis
Sepsis affects more than 1.5 million Americans annually, with about 250,000 of these patients dying...
Karius Research: Detecting Pathogen DNA in Maternal Plasma
Intra-amniotic infections (IAI) can increase the risk of obstetric complications, including spontaneous onset of labor,...
Pathogen Spotlight: Mucorales
Meet Mucor, a common mold in our environment that grows in soil and decaying organic matter....
Announcing the Karius Clinical Investigator Awards for Applied Infectious Disease Genomics
Karius to Award $100,000 in Clinical Research Grant Funds for Novel Applications of Infectious Disease...
Karius Test Used in a Nohla Phase 2 Clinical Trial for Detection of Subclinical Infections
REDWOOD CITY, Calif. – Karius, Inc., a life sciences company transforming infectious disease diagnostics with...
Karius Medical Case Report: Secondary Infections After Influenza
Influenza has significantly altered the course of human history. In the last 100 years, there...
Karius Research: How to Advance Basic Science From Within Industry
Young scientists just starting out might have the perception that academic science makes all the...
Karius Medical Case Report: Legionella pneumophila
Legionnaires’ disease is a severe form of pneumonia caused by the gram-negative bacterium Legionella pneumophila....
Current Challenges in the World of Infectious Diseases
One of our greatest challenges is the continuing global impact of infectious diseases. Infections cause...
Karius Medical Case Reports: Invasive Fungal Infections in Immunocompromised Patients
Invasive fungal infections (IFIs) are associated with significant morbidity and mortality in immunocompromised patient populations,...
How a Child Inspired Me to Bring Microbial Cell-Free DNA Research from the Lab to the World
By Mickey Kertesz, PhD
As a new entrepreneur, I often get asked “Why...
