Karius

Transforming infectious disease diagnostics with genomics

We accurately identify 1,000+ pathogens from a single blood draw to help clinicians rapidly diagnose infectious diseases.

How it Works

1,000+ pathogens
Broad, quantitative coverage of bacteria, DNA viruses, fungi, and protozoa using next-generation sequencing

tat icon

Next day results
Sample-to-answer in a clinically
actionable timeframe

One test
Highly sensitive assay on a simple blood draw may spare patients unnecessary testing, antibiotic overuse, or invasive biopsies

 

“The Karius Test has helped us save childrens’ lives that might otherwise have been lost to infections.”

Dr. Lauge Farnaes, San Diego, CA
Pediatric Hematology/Oncology and Infectious Diseases Fellow

Earlier Targeted Treatment for Sepsis

A 69-year-old male presented with sepsis and respiratory failure. Karius identified Mycobacterium tuberculosis from a plasma specimen the next day, while AFB culture from BAL fluid took 3 weeks to turn positive. The patient was able to start earlier multidrug treatment for pulmonary tuberculosis while discontinuing unnecessary antibiotics.

Invasive Fungal Infection in Immunocompromised Child

A 4-year-old girl with pre-B cell ALL presented with neutropenic fever. Karius testing identified Rhizopus oryzae after an extensive laboratory work-up for prolonged fevers came back negative. The patient ultimately underwent lung resection with tissue evaluation showing fungal elements, but she was able to initiate early antifungal treatment for invasive fungal infection prior to surgical intervention.

 

“The Karius Test is amazing. It’s going to completely change the way we diagnose and manage infectious diseases going forward.”

Dr. Ashah Shah, Stamford, CT
Infectious Diseases doctor

Comprehensive pathogen detection of over 1,000 bacteria, DNA viruses, fungi, molds and eukaryotes.

750+

Bacteria detected

Highlighted Bacteria:

Nocardia species (70)
Other Non-Tuberculous Mycobacteria species (42)
Legionella species (20)
Rickettsia species (18)
Actinomyces species (14)
Mycoplasma species (8)
HACEK organisms (including Aggregatibacter actinomycetemcomitans,
Aggregatibacter aphrophilus,
Cardiobacterium hominis,
Eikenella corrodens,
Haemophilus parainfluenzae and
Kingella kingae)
Streptobacillus moniliformis
Mycobacterium tuberculosis complex
Mycobacterium avium complex (MAC)
Mycobacterium chimaera
Other Non-Tuberculous Mycobacteria species (42)

How it Works

The Karius® Test is a send-out test that clinicians can order online. Detailed instructions for collecting and shipping specimens are available here.

PPT Tube
5 mL standard blood draw

dna

Specimen Processing
DNA extraction and library preparation

Sequencing
Pathogen DNA sequenced

dna analysis

Analysis
Curated clinical-grade microbe database

Report
Quantitative amounts of clinically relevant pathogens

How Karius Saved My Life: Brian’s Story

Dear Karius,

I am writing in heartfelt appreciation for the Karius Test, which...

Read the Post

New Clinical Study Data Published on Karius Test in Patients with Invasive Fungal Infections

We are pleased to announce the positive results of a clinical study using blood samples...

Read the Post

Diagnostic Microbiology and Infectious Disease Publishes New Clinical Study Data on Karius Test

Study Confirms Liquid Biopsy for Infectious Diseases Accurately Detects Invasive Fungal Infections

REDWOOD CITY, Calif. — ...

Read the Story

Karius Medical Case Reports: Blood Culture-Negative Endocarditis

Blood culture-negative endocarditis is an infection of the heart valves where blood cultures to...

Read the Post

Karius ASM Industry Showcase Webinar: Clinical Application of a Plasma Next-Generation Sequencing Test for Pathogen Detection

This talk was recorded at the ASM Microbe 2018 meeting on Saturday, June 9,...

Read the Post

Deadline for Karius Clinical Investigator Awards Extended to July 13

This is the month to get your application in for the Karius Clinical...

Read the Post

Karius to Present Data on The Karius Test at ASM Microbe 2018

Announces Newly Expanded, Comprehensive Genomic Diagnostic for Infectious  Diseases
Covering 1,320 Pathogens with a
...

Read the Story

Karius Webinar: Introduction and Clinical Experience with the Karius Test

This is the first of a new webinar series about the clinical use of the...

Read the Post

Fighting infectious disease with cfDNA

Read the Story

Karius Announces Launch of Quantitative, Broad-Based Infectious Disease Diagnostic Test Using Microbial Cell-Free DNA

Test Detects and Quantifies DNA from Bacteria, Viruses and Fungi in a Single Blood...

Read the Post

Karius Announces Launch of Quantitative, Broad-Based Infectious Disease Diagnostic Test Using Microbial Cell-Free DNA

Test Detects and Quantifies DNA from Bacteria, Viruses and Fungi in a Single Blood...

Read the Story

Sequencing Comes to Infectious Diseases

We’re thrilled to be featured on the Mendelspod.com podcast today, featuring Karius CEO Dr. Mickey...

Read the Post

Genomics soon to be standard for rapid ID diagnostics

Read the Story

Karius Medical Case Reports: The Race to Diagnose Sepsis

Sepsis affects more than 1.5 million Americans annually, with about 250,000 of these patients dying...

Read the Post

Karius Research: Detecting Pathogen DNA in Maternal Plasma

Intra-amniotic infections (IAI) can increase the risk of obstetric complications, including spontaneous onset of labor,...

Read the Post

Pathogen Spotlight: Mucorales

Meet Mucor, a common mold in our environment that grows in soil and decaying organic matter....

Read the Post

Announcing the Karius Clinical Investigator Awards for Applied Infectious Disease Genomics

Karius to Award $100,000 in Clinical Research Grant Funds for Novel Applications of Infectious Disease...

Read the Story

Announcing the Karius Clinical Investigator Awards for Applied Infectious Disease Genomics

Karius to Award $100,000 in Clinical Research Grant Funds for Novel Applications of Infectious Disease...

Read the Post

Nohla Therapeutics to Use Karius Pathogen Detection Test in AML Therapy Trial

Read the Story

Karius Next-Generation Sequencing Blood Test for Infectious Disease Used in a Nohla Phase 2 Cellular Therapy Clinical Trial to Enable Detection of Subclinical Infections

REDWOOD CITY, Calif. - Karius, Inc., a life sciences company transforming infectious disease diagnostics with...

Read the Story

Karius Test Used in a Nohla Phase 2 Clinical Trial for Detection of Subclinical Infections

REDWOOD CITY, Calif. – Karius, Inc., a life sciences company transforming infectious disease diagnostics with...

Read the Post

Karius Medical Case Report: Secondary Infections After Influenza

Influenza has significantly altered the course of human history.

In the last 100 years, there...

Read the Post

Karius Research: How to Advance Basic Science From Within Industry

Young scientists just starting out might have the perception that academic science makes all the...

Read the Post

Karius Medical Case Report: Legionella pneumophila

Legionnaires’ disease is a severe form of pneumonia caused by the gram-negative bacterium Legionella pneumophila....

Read the Post

Current Challenges in the World of Infectious Diseases

One of our greatest challenges is the continuing global impact of infectious diseases. Infections cause...

Read the Post

Karius Medical Case Reports: Invasive Fungal Infections in Immunocompromised Patients

Invasive fungal infections (IFIs) are associated with significant morbidity and mortality in immunocompromised patient populations,...

Read the Post

How a Child Inspired Me to Bring Microbial Cell-Free DNA Research from the Lab to the World

By Mickey Kertesz, PhD

As a new entrepreneur, I often get asked “Why...

Read the Post

Karius and UCSF Show Rapid Pathogen Detection in Stem-Cell Transplant Patients

Trial Results Presented at American Society of Hematology Annual Meeting

Read the Story

Karius Eyeing Sepsis, Transplant Patients as Key Markets for Infectious Disease Sequencing Test

Read the Story

New Data Show Karius Test Improves Pathogen Detection in Challenging Patient Populations

Karius Presenting New Data From Five Abstracts at Infectious Disease Week Annual Meeting SEP-SEQ Trial...

Read the Story

One Test May Spot Cancer, Infections, Diabetes and More

Read the Story

Karius Spots $50 Million for Rapid Detection

Read the Story

Karius Announces $50 Million in Financing for Technology Enabling Broad and Rapid Detection of Infectious Diseases

Read the Story

Karius reels in $50M to ramp up infectious disease liquid biopsy

Read the Story

Doctors say this start-up could revolutionize how we fight infectious diseases

Read the Story

How Metagenomics Is Advancing Infectious Disease Diagnostics

Read the Story

Source Code: Putting metagenomics to the test in the clinic

Read the Story

Karius Aims to Diagnose Infection From Cell-Free Microbial DNA

Read the Story

Karius Test Demonstrates Ability to Detect Pathogens from Cell-Free DNA Using Next-Generation Sequencing

Read the Story

Karius, Inc. Announces Data Presentations and Informational Session at ASM Microbe 2017

Read the Story