Transforming infectious disease diagnostics with genomics
We accurately identify 1,000+ pathogens from a single blood draw to help clinicians rapidly diagnose infectious diseases.
1,000+ pathogens
Broad, quantitative coverage of bacteria, DNA viruses, fungi, and protozoa using next-generation sequencing
Next day results
Sample-to-answer in a clinically
actionable timeframe
One test
Highly sensitive assay on a simple blood draw may spare patients unnecessary testing, antibiotic overuse, or invasive biopsies
“The Karius Test has helped us save childrens’ lives that might otherwise have been lost to infections.”
Dr. Lauge Farnaes, San Diego, CA
Pediatric Hematology/Oncology and Infectious Diseases Fellow
Earlier Targeted Treatment for Sepsis
A 69-year-old male presented with sepsis and respiratory failure. Karius identified Mycobacterium tuberculosis from a plasma specimen the next day, while AFB culture from BAL fluid took 3 weeks to turn positive. The patient was able to start earlier multidrug treatment for pulmonary tuberculosis while discontinuing unnecessary antibiotics.
Invasive Fungal Infection in Immunocompromised Child
A 4-year-old girl with pre-B cell ALL presented with neutropenic fever. Karius testing identified Rhizopus oryzae after an extensive laboratory work-up for prolonged fevers came back negative. The patient ultimately underwent lung resection with tissue evaluation showing fungal elements, but she was able to initiate early antifungal treatment for invasive fungal infection prior to surgical intervention.
How it Works
The Karius® Test is a send-out test that clinicians can order online. Detailed instructions for collecting and shipping specimens are available here.
PPT Tube
5 mL standard blood draw
Specimen Processing
DNA extraction and library preparation
Sequencing
Pathogen DNA sequenced
Analysis
Curated clinical-grade microbe database
Report
Quantitative amounts of clinically relevant pathogens
Karius Medical Case Reports: Blood Culture-Negative Endocarditis
Blood culture-negative endocarditis is an infection of the heart valves where blood cultures to...
Karius ASM Industry Showcase Webinar: Clinical Application of a Plasma Next-Generation Sequencing Test for Pathogen Detection
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Deadline for Karius Clinical Investigator Awards Extended to July 13
This is the month to get your application in for the Karius Clinical...
Karius Webinar: Introduction and Clinical Experience with the Karius Test
This is the first of a new webinar series about the clinical use of the...
Karius Announces Launch of Quantitative, Broad-Based Infectious Disease Diagnostic Test Using Microbial Cell-Free DNA
Test Detects and Quantifies DNA from Bacteria, Viruses and Fungi in a Single Blood...
Sequencing Comes to Infectious Diseases
We’re thrilled to be featured on the Mendelspod.com podcast today, featuring Karius CEO Dr. Mickey...
Karius Medical Case Reports: The Race to Diagnose Sepsis
Sepsis affects more than 1.5 million Americans annually, with about 250,000 of these patients dying...
Karius Research: Detecting Pathogen DNA in Maternal Plasma
Intra-amniotic infections (IAI) can increase the risk of obstetric complications, including spontaneous onset of labor,...
Pathogen Spotlight: Mucorales
Meet Mucor, a common mold in our environment that grows in soil and decaying organic matter....
Announcing the Karius Clinical Investigator Awards for Applied Infectious Disease Genomics
Karius to Award $100,000 in Clinical Research Grant Funds for Novel Applications of Infectious Disease...
Karius Test Used in a Nohla Phase 2 Clinical Trial for Detection of Subclinical Infections
REDWOOD CITY, Calif. – Karius, Inc., a life sciences company transforming infectious disease diagnostics with...
Karius Medical Case Report: Secondary Infections After Influenza
Influenza has significantly altered the course of human history.
In the last 100 years, there...
Karius Research: How to Advance Basic Science From Within Industry
Young scientists just starting out might have the perception that academic science makes all the...
Karius Medical Case Report: Legionella pneumophila
Legionnaires’ disease is a severe form of pneumonia caused by the gram-negative bacterium Legionella pneumophila....
Current Challenges in the World of Infectious Diseases
One of our greatest challenges is the continuing global impact of infectious diseases. Infections cause...
Karius Medical Case Reports: Invasive Fungal Infections in Immunocompromised Patients
Invasive fungal infections (IFIs) are associated with significant morbidity and mortality in immunocompromised patient populations,...
How a Child Inspired Me to Bring Microbial Cell-Free DNA Research from the Lab to the World
By Mickey Kertesz, PhD
As a new entrepreneur, I often get asked “Why...
