Transforming infectious disease diagnostics with genomics
We accurately identify 1,000+ pathogens from a single blood draw to help clinicians rapidly diagnose infectious diseases.
1,000+ pathogens
Broad, quantitative coverage of bacteria, DNA viruses, fungi, and protozoa using next-generation sequencing
Next day results
Sample-to-answer in a clinically
actionable timeframe
One test
Highly sensitive assay on a simple blood draw may spare patients unnecessary testing, antibiotic overuse, or invasive biopsies
“The Karius Test has helped us save childrens’ lives that might otherwise have been lost to infections.”
Dr. Lauge Farnaes, San Diego, CA
Pediatric Hematology/Oncology and Infectious Diseases Fellow
Earlier Targeted Treatment for Sepsis
A 69-year-old male presented with sepsis and respiratory failure. Karius identified Mycobacterium tuberculosis from a plasma sample the next day, while AFB culture from BAL fluid took 3 weeks to turn positive. The patient was able to start earlier multidrug treatment for pulmonary tuberculosis while discontinuing unnecessary antibiotics.
Invasive Fungal Infection in Immunocompromised Child
A 4-year-old girl with pre-B cell ALL presented with neutropenic fever. Karius testing identified Rhizopus oryzae after an extensive laboratory work-up for prolonged fevers came back negative. The patient ultimately underwent lung resection with tissue evaluation showing fungal elements, but she was able to initiate early antifungal treatment for invasive fungal infection prior to surgical intervention.
How it Works
The KariusTM Test is a send-out test that clinicians can order online. Detailed instructions for collecting and shipping specimens are available here.
PPT Tube
5 mL standard blood draw
Sample Processing
DNA extraction and library preparation
Sequencing
Pathogen DNA sequenced
Analysis
Curated clinical-grade microbe database
Report
Quantitative amounts of clinically relevant pathogens
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